(–)-11β,20β-Epoxy-4-deacetoxyjunceellolide D, Polyoxygenated Briarane Deriving from Octocoral Junceella fragilis in Sea Whip
Yu-Hsin Hsieh 1,2, Li-Guo Zheng 2,3, You-Ying Chen 2,4, Su-Ying Chien 5, Yun-Ting Zeng 2,4 and Ping-Jyun Sung 2,4,6,7,8*
1 Graduate Institute of Marine Biology, National Dong Hwa University, Pingtung County, Taiwan
2 National Museum of Marine Biology and Aquarium, Pingtung County, Taiwan
3 Doctoral Degree Program in Marine Biotechnology, National Sun Yat-sen University, Kaohsiung City, Taiwan
4 Department of Marine Biotechnology and Resources, National Sun Yat-sen University, Kaohsiung City, Taiwan
5 Instrumentation Center, National Taiwan University, Taipei City, Taiwan
6 Chinese Medicine Research and Development Center, China Medical University Hospital, Taichung City, Taiwan
7 Graduate Institute of Natural Products, Kaohsiung Medical University, Kaohsiung City, Taiwan
8 Ph.D. Program in Pharmaceutical Biotechnology, Fu Jen Catholic University, New Taipei City, Taiwan
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Abstract:
Through the chemical screening of an octocoral, identified as Junceella fragilis, polyoxygenated briarane-type diterpenoid, (–)-11β,20β-epoxy-4-deacetoxyjunceellolide D (1) was discovered, which was then subject to single-crystal X-ray diffraction analysis to determine its absolute structure. The structure was verified with 2D NMR experiments, supplemented with a literature review. At the same time, conformation of previously-discovered briarane, (–)-11α,20α-epoxy-4-deacetoxyjunceellolide D was evaluated.
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