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Mar. Res. 2023/06
Vol.3. Iss.1 :43-51
DOI:10.29677/MR.202306_3(1).0003
(–)-11β,20β-Epoxy-4-deacetoxyjunceellolide D, Polyoxygenated Briarane Deriving from Octocoral Junceella fragilis in Sea Whip

Yu-Hsin Hsieh 1, Li-Guo Zheng 2, You-Ying Chen 3, Su-Ying Chien 4, Yun-Ting Zeng 3 and Ping-Jyun Sung 5
1Graduate Institute of Marine Biology, National Dong Hwa University, Pingtung County, Taiwan; National Museum of Marine Biology and Aquarium, Pingtung County, Taiwan
2National Museum of Marine Biology and Aquarium, Pingtung County, Taiwan; Doctoral Degree Program in Marine Biotechnology, National Sun Yat-sen University, Kaohsiung City, Taiwan
3National Museum of Marine Biology and Aquarium, Pingtung County, Taiwan; Department of Marine Biotechnology and Resources, National Sun Yat-sen University, Kaohsiung City, Taiwan
4Instrumentation Center, National Taiwan University, Taipei City, Taiwan
5National Museum of Marine Biology and Aquarium, Pingtung County, Taiwan; Department of Marine Biotechnology and Resources, National Sun Yat-sen University, Kaohsiung City, Taiwan; Chinese Medicine Research and Development Center, China Medical University Hospital, Taichung City, Taiwan; Graduate Institute of Natural Products, Kaohsiung Medical University, Kaohsiung City, Taiwan; Ph.D. Program in Pharmaceutical Biotechnology, Fu Jen Catholic University, New Taipei City, Taiwan


Abstract: Through the chemical screening of an octocoral, identified as Junceella fragilis, polyoxygenated briarane-type diterpenoid, (–)-11β,20β-epoxy-4-deacetoxyjunceellolide D (1) was discovered, which was then subject to single-crystal X-ray diffraction analysis to determine its absolute structure. The structure was verified with 2D NMR experiments, supplemented with a literature review. At the same time, conformation of previously-discovered briarane, (–)-11α,20α-epoxy-4-deacetoxyjunceellolide D was evaluated.

Keywords:  Junceella fragilis, briarane, junceellolide, absolute configuration, single-crystal X-ray diffraction.

 
*Corresponding author; e-mail: pjsung@nmmba.gov.tw
© 2023  Marine Research , ISSN 2709-6629 




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